A case of invasive cribriform carcinoma of the carcinoma of the breast is presented with fine needle aspiration cytologic features. The aspiration was performed from a papable 2.0cm mass in the upper outer quadrant of the right breast in a 53
year-old woman. The aspirate showed cellular smear composed of larger three dimensional tight clusters, smaller monolayered loose clusters, and many individual cells on the clean background. In the clusters, the tumor cells
were
bordering central lumina, quite similar to the cribriform in histology. The tumor cells in the clusters and individual tumor cells and unifrom, small and round nuclei. The chromatin was finely granular, and nuclear membrane was
smooth,
No
discernible nucleoli were present(nuclear grade 1~2). Unless the abundance of individual cells and the cribrifoim growth pattern are recognized in the smear, the cytologic diagnosis of invasive cribriform carcinoma is difficult.
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